國家衛生研究院 NHRI:Item 3990099045/4924

NHRI > National Institute of Environmental Health Sciences > Hung-Che Chiang > Periodical Articles > Item 3990099045/4924

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4924

Title:	Management of a nosocomial outbreak of mycobacterium tuberculosis Beijing/W genotype in Taiwan: An emphasis on case tracing with high-resolution computed tomography
Authors:	Chen, TC;Lu, PL;Yang, CJ;Lin, WR;Lin, CY;Jou, R;Feng, MC;Wang, TH;Ho, CK;Hwang, JJ;Chen, YH;Chiang, HC;Huang, MS;Chen, TP
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	A nosocomial outbreak of Mycobacterium tuberculosis Beijing/W genotype infected 15 healthcare workers (HCWs) in a medical center in Taiwan, where there is a high prevalence of tuberculosis and a high rate of positive tuberculin skin tests. An index patient with laryngeal cancer and a lung abscess was identified by epidemiological investigation and it was found that an M. tuberculosis isolate from his lung tissue sample had an identical IS6110 restriction fragment length polymorphism pattern to the isolates from 3 HCWs. Confirmation of the identity of this strain as Beijing/W genotype was made using spoligotyping. Seven hundred and eighty-five HCWs potentially exposed to the probable index patient received contact investigation and chest X-ray screening. We used chest high-resolution computed tomography (HRCT) to clarify trivial lesions in chest X-rays. Nine HCWs with smear-negative pulmonary tuberculosis were diagnosed by HRCT. Fifteen of the 35 (42.9%) HCWs with documented exposure to the index patient developed pulmonary tuberculosis within 11 months after exposure. The outbreak was successfully controlled by active case finding and enforcement of infection control strategies. Intervention to detect the potential tuberculosis source is helpful in the prevention and control of a nosocomial tuberculosis outbreak. HRCT can be a useful tool for tuberculosis diagnosis of contacts in an outbreak situation.
Date:	2010
Relation:	Japanese Journal of Infectious Diseases. 2010;63(3):199-203.
Link to:	http://www.nih.go.jp/JJID/63/199.html
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1344-6304&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000278391500010
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77953348853
Appears in Collections:	[Hung-Che Chiang] Periodical Articles

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