國家衛生研究院 NHRI:Item 3990099045/4900
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    題名: Overexpression of 14-3-3 epsilon predicts tumour metastasis and poor survival in hepatocellular carcinoma
    其他題名: Overexpression of 14-3-3ε predicts tumour metastasis and poor survival in hepatocellular carcinoma
    作者: Ko, BS;Chang, TC;Hsu, C;Chen, YC;Shen, TL;Chen, SC;Wang, J;Wu, KK;Jan, YJ;Liou, JY
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Aims:  The results of our earlier studies suggested that 14-3-3ε is involved in cancer cell survival and growth. However, it is not clear whether 14-3-3ε plays a role in tumour metastasis and patient outcome. The aim of this study was to determine whether 14-3-3ε is a marker for predicting hepatocellular carcinoma (HCC) metastasis and survival. Methods and results:  One hundred and fourteen patients with tissue-diagnosed primary HCC were followed for an average of 58.6 months. 14-3-3ε in liver tissues was analysed by immunohistochemistry, and quantified by a Quick score system. Correlation of 14-3-3ε with patient survival and metastasis was analysed with a Wilcoxon signed rank test, Kaplan-Meier survival curves, and Cox proportional hazard regression. Seventy-one of 114 patients (62.3%) had a significant increase of 14-3-3ε expression in HCC tissues, whereas normal tissues expressed weak or undetectable 14-3-3ε. Elevated 14-3-3ε expression was significantly associated with shortened overall survival and progression-free survival. Furthermore, 14-3-3ε overexpression increased the risk of metastasis 4.6-fold.
    日期: 2011-04
    關聯: Histopathology. 2011 Apr;58(5):705-711.
    Link to: http://dx.doi.org/10.1111/j.1365-2559.2011.03789.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0309-0167&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289465400006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79954589542
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