國家衛生研究院 NHRI:Item 3990099045/4895
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    題名: Comparative tissue distributions of cadmium chloride and cadmium-based quantum dot 705 in mice: Safety implications and applications
    作者: Yeh, T. K.;Wu, J. P.;Chang, L. W.;Tsai, M. H.;Chang, W. H.;Tsai, H. T.;Yang, C. S.;Lin, P. P.
    貢獻者: Center for Nanomedicine Research;Division of Environmental Health and Occupational Medicine;Division of Biotechnology and Pharmaceutical Research
    摘要: Cadmium (Cd) is a component in quantum dot 705 (QD705). Whether QD705 behaves similar to Cd in vivo is of great concern. We compared the distributional kinetics of cadmium chloride (CdCl2) and QD705 in mice after intravenous injection. QD705 showed a longer plasma and body retention than CdCl2 and could be detected in the brain during early exposure. While both the liver and spleen demonstrated a constant Cd concentration for 28 days after QD705 injection, it is likely that this represents intact QD705 stored in mononuclear phagocytes. The kidneys showed a time-dependent accumulation of Cd in the QD705-exposed animals. By day 28, Cd in the kidneys from QD705 was 3-fold that of CdCl2. QD705 and CdCl2 have very different kinetics in distribution and metabolism. The long body retention of QD705 in the kidneys may mean that QD705 has even more renal toxicity than CdCl2.
    日期: 2011-03
    關聯: Nanotoxicology. 2011 Mar;5(1):91-97.
    Link to: http://dx.doi.org/10.3109/17435390.2010.502260
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1743-5390&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288545400008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952846226
    顯示於類別:[楊重熙] 期刊論文
    [林嬪嬪] 期刊論文
    [葉燈光] 期刊論文
    [張惠華(1999-2009)] 期刊論文

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