Starting from 4,4-dimethyl-2-cyclohexenone, an enantioselective synthesis of (–)-isopisiferin has been accomplished in 15 steps with an overall yield of 11.4%. This work not only provides synthetic evidence for confirming the absolute con-figuration of natural isopisiferin itself, but also serves as an additional correlation origin to which many related icetexane-type diterpenes, particular for the pisiferin family, can be referred.
Date:
2010-08
Relation:
Journal of Organic Chemistry. 2010 Aug;2010(22):4271-4275.
