國家衛生研究院 NHRI:Item 3990099045/4833
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4833


    Title: A Bayesian approach to virus-gene expression time course data
    Other Titles: Emerging Information Technology Conference 2005
    Authors: Chang, IS;Wen, CC;Wu, YJ;Gupta, PK;Jiang, SS;Juang, JL;Hsiung, CA
    Contributors: National Institute of Cancer Research;Division of Molecular and Genomic Medicine;Division of Biostatistics and Bioinformatics
    Abstract: We propose a Bayesian regression model to study the time course expression profile of a virus-gene using data from micro-array experiments. Since the time course expression level of a virus gene in a cell is typically constantly zero initially, increasing for a while, and then decreasing, we consider regression model in which the mean function satisfies the above shape restriction. The prior is introduced through Bernstein polynomials. We note that Bernstein polynomial provides an excellent tool to incorporate geometric information into priors for Bayesian inference. We use the Metropolis-Hastings-Green algorithm to generate the posterior distribution and use the posterior mode as the estimate. This method is illustrated in simulation studies and analysis of real datasets. In this extended abstract, we include the expression profile of one of the genes of Baculavirus, obtained from the Bayesian method of this work. In the talk, I will also discuss applications of the expression profiles in the study of the virus genome. c 2005 IEEE.
    Date: 2005-08
    Relation: Emerging Information Technology Conference 2005. 2005 Aug;170-171(Article number 1544357).
    Link to: http://dx.doi.org/10.1109/EITC.2005.1544357
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236376100052
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33751171529
    Appears in Collections:[I-Shou Chang] Conference Papers/Meeting Abstract
    [Jyh-Lyh Juang] Conference Papers/Meeting Abstract
    [Chao A. Hsiung] Conference Papers/Meeting Abstract
    [Shih-Sheng Jiang] Conference Papers/Meeting Abstract

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