國家衛生研究院 NHRI:Item 3990099045/4801
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4801


    Title: The signals of FGFs on the neurogenesis of embryonic stem cells
    Authors: Chen, CW;Liu, CS;Chiu, IM;Shen, SC;Pan, HC;Lee, KH;Lin, SZ;Su, HL
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Background: Neural induction is a complex process and the detailed mechanism of FGF-induced neurogenesis remains unclear. Methods: By using a serum-free neural induction method, we showed that FGF1 dose-dependently promoted the induction of Sox1/N-cadherin/nestin triple positive cells, which represent primitive neuroblasts, from mouse embryonic stem (ES) cells. Results: We demonstrated that FGF1, FGF2, and FGF4, but not FGF8b, enhanced this neurogenesis. Especially, FGF-enhanced neurogenesis is not mediated through the rescue of the apoptosis or the enhancement of the proliferation of Sox1+ cells. We further indicated that the inactivation of c-Jun N-terminal kinase-1 (JNK-1) and extracellular signal-related kinase-2 (ERK-2), but not p38 mitogen-activated protein kinase (MAPK), inhibited the neural formation through the inhibition of ES differentiation, but not through the formation of endomesodermal cells. Conclusions: These lines of evidence delineated the roles of FGF downstream signals in the early neural differentiation of ES cells.
    Date: 2010-04
    Relation: Journal of Biomedical Science. 2010 Apr;17:Article number 33.
    Link to: http://dx.doi.org/10.1186/1423-0127-17-33
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-7770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000278272800001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951563748
    Appears in Collections:[Ing-Ming Chiu] Periodical Articles

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