This paper proposes a novel method by employing gold-nanoparticle to enhance optic fiber Fabry-Perot (F-P) interferometry signal for bio-molecule detection. PDMS dip coating and self-assembly monolayers were employed to prepare the fiber probes in the formation Of F-P cavity and modification of the tip surface, respectively. Cysteine molecules were immobilized on the sensor surface to allow gold-nanoparticles attachment in the experiment. Experiment result shows that the signal amplitude has more than 40% enhancement and the spectrum shift can be improved by one order of magnitude when employing 40 nm nanoparticles compare to the traditional detection ways by Febry-Perot interferometry. This result provides a minimum detectable gold-nanoparticles concentration of 1 > 10(7) particles/mu l for 40 nm particle diameter enhanced optic fiber Febry-Perot interferometry.
Date:
2005-07
Relation:
2005 5th IEEE Conference on Nanotechnology. 2005 Jul;2:1764-1767.
