國家衛生研究院 NHRI:Item 3990099045/4782
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    题名: Crystal structures and computer screened inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase
    其它题名: Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
    作者: Kuo, CJ;Guo, RT;Lu, IL;Liu, HG;Wu, SY;Ko, TP;Wang, AHJ;Liang, PH
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Helicobacter Pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPs), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In the present study, X-ray structural analysis and computer virtual screening of inhibitors were performed for H. pylori UPPs. The 3-D structure of H. pylori UPPs was solved, with subtle variations from that of E. coli UPPs. Using the structures, two hits identified from 58,635 compounds through computer virtual screening displayed differential activities against H. pylori and E. coli UPPs.
    日期: 2007
    關聯: Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. 2007:305-310(Article number 4524124).
    Link to: http://dx.doi.org/10.1109/FBIT.2007.34
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000256289300056
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=49349101138
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