國家衛生研究院 NHRI:Item 3990099045/4765
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    题名: Gait speed, lower body strength, and levels of homocysteine in the elderly
    作者: Kuo, HK;Yen, CJ
    贡献者: Division of Gerontology Research
    摘要: Background: Evidence suggests that elevated homocysteine (Hcy) levels maycause toxicity by such mechanisms as oxidative stress, endothelial damage, and neurotoxicity and have been linked to various age-related disorders including vascular disease, depression, and dementia.However, little is known about whether physical function is affected by elevated levels of Hcy.The aim of this study was to analyze the impact of Hcy levels on physical functions including gait speed and lower body strength in otherwise healthy elders. Method:We analyzed 3030 subjects aged 50 and older who completedmuscle strength and timed walk examinations in the National Health and Nutrition Examination Survey 1999-2002. Lower body strength was assessed by determination of is okinetic strength of the knee extensor.Maximal voluntary concentric muscle force (Newton) was measured in the right knee extensor at an angular velocity of 60 degree/second. Knee extensor peak torque was calculated as (peakforce in Newton*mechanical arm length in cm)/100 [N-m].The timed walk test consisted of a 20-foot walk at the subjects’ usual pace. Walktime was measured and gait speed was obtained as meter/second(m/sec). Levels of Hcy were log-transformed due to right skewness.Age, sex, race, levels of nutritional markers (folate and vitamin B12),presence of diabetes, averaged systolic blood pressure, smoking status,body mass index, alcohol consumption, self-report health condition,and history of stroke, myocardial infarction, congestive heart failure, and angina were obtained according to the NHANES protocol and adjusted as covariates. Multiple linear regression was used to examine the association between knee extensor muscle strength, gait speed, and levels of homocysteine. Results: After multivariate adjustment, each increment of 1 standard deviation(SD) in the log-transformed Hcy level was associated with a1.63 N-m decrease in knee is okinetic peak torque (95% CI -2.73 to -0.53, p=0.004).There was a 0.02 m/sec decrease in gait speed (95% CI-0.03 to -0.01, p<0.0001) for each SD increase in the log-trans formed Hcy level in the multivariate model. Additional adjustment for use of walking device and pain reported in walking did not change the association between gait speed and levels of Hcy. Conclusion:Levels of Hcy were inversely associated with knee extensor muscle strength and gait speed in the elderly people.
    日期: 2005-04
    關聯: Journal of the American Geriatrics Society. 2005 Apr;53(4):S66.
    Link to: http://dx.doi.org/10.1111/j.1532-5415.2005.05304003.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-8614&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000228450900187
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