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http://ir.nhri.org.tw/handle/3990099045/4715
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| Title: | Chronic kidney diseases increase risk of mortality in elderly - A cohort study in southern Taiwan |
| Authors: | Hwang, SJ;Lin, MY;Mau, LW;Hwang, SC;Chen, HC;Yang, WC;Hsu, CC;Chu, HC |
| Contributors: | Division of Health Policy Research and Development |
| Abstract: | Introduction and Aims: The risk of death increased in patients with ESRD and also in chronic kidney diseases (CKD), however only few studies have been reported in Asian elderly. Taiwan has extreme high incidence and prevalence of end stage renal diseases (ESRD) in the world, and both rank top in groups with age 65 to 75 and over 75 years. The aims of this study were to investigate the prevalence of CKD in elderly and to evaluate the risks of mortality of the elderly with different grades of glomerular filtrationrate (GFR) in Taiwan.Methods: This study was conducted retrospectively through a longitudinal cohort study analyzing clinical and laboratory data from 35,555 elderly people with age over 65 years, who took annual physical check up in Kaohsiung City in year 2002. Estimated GFR was calculated by simplified MDRD formula. For survival analysis multivariable association between GFR and the risks of death by Cox regression and proportion hazard models were done.Results: The mean of tracing time was 30.6±3.9 months. The mean age was 75.7±5.3 years, and 59.4 percent of the subjects were man. The crude prevalence rate of chronic kidney diseases (CKD) stage 3-5 was39.4%, much higher than that in general population. There were 1,930subjects died during the follow up period. After adjustment for age, sex,proteinuria, albumin, hemoglobin, and metabolic syndrome, the risks of all cause death increased as the eGFR decreased below 60 ml/min/1.73m2.Comparing to the reference group with eGFR over 60 ml/min/1.73m2,the adjusted hazard ratio for all cause mortality was 1.2 for group with GFR of 45 to 59 ml/min/1.73m2 (CKD IIIa), 1.5 for group with eGFRof 30 to 44 ml/min/1.73m2 (CKD IIIb), 2.1 for group with eGFR of 15to 29 ml/min/1.73m2 (CKD IV), and 3.0 for group with eGFR of lessthan 15 ml/min/1.73m2 (CKD V). Significant different in hazard ratio ofcardiovascular and renal disease mortality were noted but not in malignancy and DM mortality as the decrease in eGFR.Conclusions: High CKD prevalence could be responsible for the high ESRD incidence in elderly in Taiwan. Reduced eGFR is associated with increase of the risk of death in elderly people with various stages of CKD. These findings suggest CKD is a significantly risk factor in elderly people in southern Taiwan. |
| Date: | 2006-07 |
| Relation: | Nephrology Dialysis Transplantation. 2006 Jul;21(Suppl. 4):122. |
| Link to: | http://ndt.oxfordjournals.org/content/21/suppl_4.toc |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0931-0509&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000239919001017 |
| Appears in Collections: | [許志成] 會議論文/會議摘要
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| ISI000239919001017.pdf | | 79Kb | Adobe PDF | 556 | View/Open |
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