國家衛生研究院 NHRI:Item 3990099045/4689

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Title:	Quantifying the risks of mesothelioma and lung cancer from environmental crocidolite exposure in Da-yao, China
Authors:	Cheng, TD;Wen, CP
Contributors:	Division of Health Policy Research and Development
Abstract:	Background: Da-yao is a rural county located in the Southwestern China, witha quarter million population. Part of its land surface is patch-like covered bycrocidolite ore, and it has been widely used in the infrastructure of the county.The industry of clay stoves had caused signiﬁcant crocidolite exposure amongworkers and family members in the last several decades. Thus, residents havebeen at risk of being exposed to crocidolite dust from birth. The mortality riskfrom environmental crocidolite is not well established and its attributable fractionto mesothelioma or lung cancer has never been reported. The objective of thisstudy is to quantify the Rate Ratios (RRs) for mesothelioma from crocidoliteexposure and crocidolite-attributable fraction of lung cancer.Methods: The data came from the update of a 15-year (1987-2001) follow-upof 6,254 residents presented in journal Occup Environ Med 2003; 60:35-42. Atotal of 20 deaths of mesothelioma and 56 deaths of lung cancer, among 1,165total deaths, were observed. RRs were calculated by comparing rates from Da-yao with respective rates from Taiwan, where no crocidolite exposure is known.Results: Mortality rates of mesothelioma in Da-yao cohort were 23.2 and 18.7per 100,000 for males and females, and in Taiwan, 0.12 and 0.06, respec-tively. The RRs of crocidolite exposure for mesothelioma were 227 and 311in males and females, respectively. Given the mortality rate difference for lungcancer (65.1/100,000 for Da-yao and 30.2/100,000 for Taiwan), and the preva-lence difference for smoking (43% in Da-Yao and 26% in Taiwan), we found thecrocidolite-attributable fraction of lung cancer to be close to one third (36%) ofall lung cancer deaths.Conclusions: The mesothelioma risk from environmental crocidolite exposurewas approximately 269 times greater in this community than in Taiwan. Thecrocidolite-attributable lung cancer in Da-yao was about to one third of all lungcancer mortality.
Date:	2006-10
Relation:	Lung Cancer. 2006 Oct;54(Suppl. 1):S33.
Link to:	http://dx.doi.org/10.1016/S0169-5002(07)70209-X
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0169-5002&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000241900400134
Appears in Collections:	[Chi-Pang Wen(2001-2010)] Conference Papers/Meeting Abstract

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