國家衛生研究院 NHRI:Item 3990099045/4681

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Title:	Additional new 5,6-dihydroflavanones and cytotoxic constituents from the leaves of Cryptocarya chinensis
Authors:	Chou, TH;Chen, JJ;Lee, SJ;Huang, HY;Chen, IS
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Cryptocarya chinensis (Hance) Hemsl. (Lauraceae) is a medium-sized evergreen tree, distributed in southern China, Japan, and Taiwan [1]. Approximately 1400 species of Formosan plants have been screened for cytotoxicity, and C.chinensis was shown to be one of the active species. Pavine alkaloids and their derivatives have been extensively studied from the basic fraction of this species [2-6]. However, the neutral-CHCl3 soluble fraction of this plant has not been studied. Investigation of the neutral-CHCl3 soluble fraction of the leaves of C.chinensis has led to the isolation of additional four new 5,6-dihydroflavanone skeleton, cryptochinenone A (1), B (2), C (3) and D (4), together with ten known compounds. Among the all isolates, infectocaryone, crytocaryone, 4'-dihydroxy-2',6'-dimethoxychalcone, cryptocaryanone A and B showed cytotoxic activities (≤ 7.25 µg/mL) against MCF-7, NCI-H460 and SF-268 cell lines, respectively. The structures of these new compounds were determined through spectroscopic analyses including extensive 2D-NMR, X-ray, and CD-ORD data. This poster describes the structural elucidation of these new compounds and the cytotoxic activities.
Date:	2009-07
Relation:	Planta Medica. 2009 Jul;75(9):987-988.
Link to:	http://dx.doi.org/10.1055/s-0029-1234640
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000268806600407
Appears in Collections:	[Shiow-Ju Lee] Conference Papers/Meeting Abstract

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