國家衛生研究院 NHRI:Item 3990099045/4677

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Title:	Secondary metabolites and cytotoxic activity of the stem bark of Litsea akoensis
Authors:	Chen, IS;Chang, SY;Cheng, MJ;Kuo, YH;Lee, SJ;Chang, HS
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Six new butanolides, two with 1,2-dioxane moieties: litseadioxanin A (=rel-(2E,3S,4R)-dihydro-2-(10-(3,6-dihydro-1,2-dioxin-3-yl)decylidene)-3-hydroxy-4-methylfuran-1(3H)-one (1), litseadioxanin B (=rel- (2Z,3S,4R)-dihydro-2-(10-(3,6-dihydro-1,2-dioxin-3-yl)decylidene)-3-hydroxy-4-methylfuran-1(3H)-one (2), and another four: litseatrinolide A (=rel-(2E,3S,4R)-dihydro-3-hydroxy-2-((E)-11,14-dihydroxytetradec-12-enylidene)-4-methylfuran-1(3H)-one (3), litseatrinolide B (=rel-(2Z,3S,4R)-dihydro-3-hydroxy-2-((E)-11,14-dihydroxytetradec-12-enylidene)-4-methylfuran1-(3H)-one (4), litseakolide D1 (=(2Z,3S,4R)-dihydro-3-hydroxy-4-methyl-2-(tetradec-13-enylidene)furan-1(3H)-one (5), and litseakolide D2 (=(2E,3S,4R)-dihydro-3-hydroxy-4-methyl-2-(tetradec-13-enylidene)furan-1(3H)-one (6), were isolated from the stem bark of Litsea akoensis Hay. (Lauraceae), together with six known compounds (7-12). Their structures were characterized by in-depth NMR-spectroscopic and mass-spectrometric analyses. Butanolides 1-4, a mixture of 6 and 8, and 9 were tested against human tumor cells, including MCF-7 (human breast adenocarcinoma), NCI-H460 (non-small-cell lung cancer) and SF-268 (glioblastoma cells) cell lines. Among the isolates, litsenolide B1 (9) exhibited marginal cytotoxic activity against MCF-7, NCI-H460 and SF-268 cell lines in vitro.
Date:	2008-07
Relation:	Planta Medica. 2008 Jul;74(9):1071.
Link to:	http://dx.doi.org/10.1055/s-0028-1084480
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000258261801055
Appears in Collections:	[Shiow-Ju Lee] Conference Papers/Meeting Abstract

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