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http://ir.nhri.org.tw/handle/3990099045/4673
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| Title: | Decline of Maternal Neutralizing Antibody Against Enterovirus Type 71 (EV71) in Young Infants in Northern Taiwan |
| Authors: | Luo, ST;Chiang, PS;Chao, AS;Lin, R;Lin, TY;Lee, MS |
| Contributors: | Vaccine Research and Development Center |
| Abstract: | Background: Clinical spectrum of EV71 infection ranges from mild hand-foot-mouth disease (HFMD) to severe cases with central nervous system and cardiopulmonary involvements. In 1998, Taiwan suffered a nation-wide EV71epidemic with 405 reported severe cases and 78 fatal cases.Since then, EV71 has been endemic in Taiwan and development of EV71 vaccines has become a national priority. This cohort study was designed to understand decline of maternalEV71 neutralizing antibody titers and age-specific incidence rates of EV71 infection in Taiwan, which will be crucial for designing efficacy trials of EV71 vaccines. Methods: This study is a prospective longitudinal cohort study and was approved by the Institutional Review Boardsin CGMH and NHRI. Pregnant women having prenatal exams were invited to participate. Sera were collected from participating mother/baby for measuring EV71 neutralizing antibody titers in the following schedules: last trimester from mother, umbilical cord blood at birth, and children at6, 12, 24, 36, and 48 months old. Results: The recruitment started in June 2006. By January 2008, 201 longitudinal serum specimens collected from mothers, neonates, and 6-month-old babies (one mother delivered twins) have been measured with EV71 neutralizing antibody titers. The seropositive rates (percentage ofantibody titer ≥ 1:8) in mothers, neonates, and 6-month-old babies were 61%(122/201), 46%(93/202), and 0%(0/202),respectively. Geometric mean titers (95% confidence inter-vals) of serum EV71 antibody in mothers and neonates were10.2 (8.7, 11.5) and 8.5 (7.4, 9.7), respectively. Conclusions: In northern Taiwan, only 46% of neonates have protective antibody against EV71 and these maternal antibody titers have declined to undetectable level (<8) by6 months of age. Historical data in the 1998 epidemic also showed that infants under 1 year old had the highest risk of severe EV71 infection. Therefore, development of EV71vaccines in Taiwan should target infants under 6 months old. |
| Date: | 2008-12 |
| Relation: | International Journal of Infectious Diseases. 2008 Dec;12(Suppl. 1):E299-E300. |
| Link to: | http://dx.doi.org/10.1016/j.ijid.2008.05.803 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1201-9712&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000263287800748 |
| Appears in Collections: | [李敏西] 會議論文/會議摘要
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| ISI000263287800748.pdf | | 61Kb | Adobe PDF | 597 | View/Open |
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