國家衛生研究院 NHRI:Item 3990099045/4668
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856831      線上人數 : 935
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/4668


    題名: Microsomal epoxide hydrolase activity in healthy adult females
    作者: Wu, KY;Chen, WY;Lee, CM
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Microsomal epoxide hydrolase (mEH) is one of the major detoxification enzymes for epoxides. Polymorphism of EPHX has been associated with increases in the risk of several cancer incidences. Activity of this enzyme was reported potentially related to hormones. Currently, little information is available concerning to the association of polymorphism of EPHX or hormone levels with mEH activity in human. The purpose of this study was to fully characterize mEH activity in one month period among females. Six health adult females were recruited, and 8 ml of blood was repeatedly collected from each study subject on a regular period of 3– 4 days in one month. Blood samples were immediately separated into serum and red blood cells. mEH activity was determined by its catalysis of styrene oxide to styrene glycol in human erythrocyte cytosol. The concentration of styrene glycol was extracted using ethyl acetate and analyzed by an HPLC system connected to an UV detector. Genetic polymorphism of EHHX was also analyzed. Results show that mEH activity varied with time in each individual. Summarization of the variation patterns among the 6 subjects exhibits that mEH activity could be dependent on menstrual cycles despite of inter-individual variation, and further confirms that mEH activity is hormone-dependent in humans. The ongoing analysis of 11 hormones in serum collected from these 6 subjects using liquid chromatography coupled with tandem mass spectrometry will shed light on the relationships of mEH activity with hormone levels in females.
    日期: 2004-06
    關聯: Toxicology and Applied Pharmacology. 2004 Jun;197(3):195.
    Link to: http://dx.doi.org/10.1016/j.taap.2004.04.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0041-008X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222348900205
    顯示於類別:[吳焜裕(2001-2008)] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000222348900205.pdf41KbAdobe PDF573檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋