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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4667


    Title: Associations between exposure to polycyclic aromatic hydrocarbons and temporal change of urinary 1-hydroxypyrene levels in Taiwan coke-oven workers
    Authors: Lin, YC;Pan, CH;Chen, CJ;Wu, KY;Chang-Chien, GP;Ho, CK;Wu, TN;Chuang, HY;Kuo, HW;Wu, MT
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: Introduction:Epidemiologic studies have presented strong evidence that workers with long-term exposure to coke-oven emissions have a high incidence of cancer. Urinary 1-hydroxypyrene (1-OHP) has been used as a reliable biomarker of total environmental PAH exposure. The association between PAH exposure and the temporal change of urinary 1-OHP remains unclear.Methods:Between October, 2003 and March, 2004, 52 coke-oven workers were recruited from a large steel company in southern Taiwan. Participants provided personal air samples for PAH exposure, urine samples for 1-OHP, and interview questionnaires for demographic data and potential confounding variables. Two work-period air samples and a total of 8 spot urine samples (3 pre-shift, 3 post-shift, and 2 morning samples on days off) were analyzed using gas chromatography, mass spectrometry, and high-performance liquid chromatography with fluorescence detection.Results:Topside-oven workers had significantly higher levels of PAH exposure and 1-OHP (251.3 ± 25.9 vs. 62.4 ± 18.1 mg/g creatinine, P < 0.0001) than side-oven workers did. Urinary 1-OHP levels were significantly and positively correlated with different PAH species exposure (r = 0.29-0.55). Urinary 1-OHP increased with the number of working days. After 2 days off, urinary 1-OHP levels dramatically decreased and approached the pre-shift levels of the first working day. On days off, side-oven workers who smoked showed a slight increase in urinary 1-OHP levels.Discussion and Conclusions:We suggest that the temporal change of urinary 1-OHP levels is different between top-side and oven-side workers. Smoking can partially explain the difference in urinary 1-OHP of days off in oven-side workers. Coke-oven workers are exposed to high levels of PAHs. The working cycle requires further investigation to reduce exposure to PAHs and create a more healthful environment for coke-oven workers.
    Date: 2006-11
    Relation: Epidemiology. 2006 Nov;17(6):S188.
    Link to: http://journals.lww.com/epidem/Fulltext/2006/11001/Associations_Between_Exposure_to_Polycyclic.477.aspx
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1044-3983&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241443401006
    Appears in Collections:[吳焜裕(2001-2008)] 會議論文/會議摘要

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