國家衛生研究院 NHRI:Item 3990099045/4637

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Title:	Comparison of the antitumor activity of thalidomide between hepatitis B (HBV)and hepatitis C (HCV)-related hepatocellular carcinoma (HCC)
Authors:	Hsu, C;Chen, LT;Lai, MY;Yeh, KH;Lee, PH;Cheng, AL
Contributors:	National Institute of Cancer Research
Abstract:	Background: Previous studies suggested that chronic HCV infection may be more angiogenic than chronic HBV infection. In this study we sought to clarify if HCV- and HBV-related HCC may respond differently to thalidomide, an anti-angiogenic agent. Methods: One hundred and twelve patients with unresectable and non-embolizable HCC who had participated in 2 prospective clinical trials using single-agent thalidomide. The starting dose of thalidomide was 200 mg per day, and was gradually escalated in 100-mg steps if no limiting toxicities developed. Patients with positive serum HBV surface antigen (HBsAg) and negative anti-HCV antibody were categorized as HBV-related HCC (B-HCC, n=61), while patients with negative HBsAg and positive anti-HCV were categorized as HCV-related HCC (C-HCC, n=33). Response to thalidomide was defined by either (1) a complete or partial response according to WHO criteria or (2) a more than 50% decrease of serum α-fetoprotein level accompanied by clinically stable or improved condition lasting for more than 8 weeks for patients with elevated α-fetoprotein level. Results: All major clinicopathological features were comparable between the 2 groups except for age (C-HCC, 67.5 ± 7.6 years; B-HCC, 53.6 ± 13.7 years, p< 0.001). Eight patients with B-HCC and 9 patients with C-HCC responded to thalidomide treatment. The total response rate to thalidomide was 13.1% (95% C.I. 4.4 to 21.8%) for B-HCC and 27.3% (95% C.I. 11.2 to 43.3%) for C-HCC (p=0.09). Patients with C-HCC appeared to have better median time to disease progression (14.1 weeks vs. 8.3 weeks, p=0.03) and overall survival (32.6 weeks vs. 21.4 weeks, p=0.08) than patients with B-HCC. In multivariate analysis, staging (CLIP score), performance status and types of viral infection were independent predictors for overall survival (p<0.01), while only types of viral infection was independent predictor for time to disease progression (p=0.027). Conclusions: There is a trend favoring better anti-tumor activity of thalidomide in patients with HCV-related HCC. Whether this result is related to angiogenesis inhibition remains to be determined.
Date:	2004-07
Relation:	Journal of Clinical Oncology. 2004 Jul;22(14):Abstract number 362S.
Link to:	http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=26&abstractID=2718
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0732-183X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000223512401436
Appears in Collections:	[Li-Tzong Chen] Conference Papers/Meeting Abstract

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