國家衛生研究院 NHRI:Item 3990099045/4621
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    题名: Body burden of cadmium and its relations to exposure factors and erythrocyte parameters in an industrial area of Taiwan
    作者: Wang, SL;Yu, ST;Chang, FH;Liou, SH;Wang, YC
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Introduction:Cadmium bioaccumulate in human body and may result in health effects including anemia, renal dysfunction, and cancers. The environmental cadmium levels were found high in certain areas in Taiwan. However, detailed human data remained to be elucidated. This aim is to assess cadmium body burden and related factors on exposure and health effects in the environmentally high exposure area of Taiwan.Method:This is a community based study in central Taiwan where soil survey revealed high cadmium concentrations. A total of 660 subjects were randomly sampled from age (35-64 years) and gender stratified general population during 2002. Data collection included occupational, life style, etc. using structurized questionnaire for each subject. Whole blood and first urine were collected in fasting state in the morning. Cadmium was analyzed by Inductively Coupled Plasma / Mass Spectrometer (ICP/MS). Erythrocyte and related parameters were analyzed in central laboratory of Chang-Hua Christian Hospital. Blood Smear was carried out for each subject. Multiple linear regression model was utilized to evaluate the association of various parameters.Results:Odds ratios for blood cadmium level significantly increased from 0.98, 1.08, 1.27, and 1.35 ug/L for non-smokers, ex-smokers, <21 cigarettes per day, and ≥21 in men after the adjustment of age, occupation, and dietary habits. In women, Blood cadmium concentration was significantly (p<0.01) associated with decreasing Mean Corpuscular Haemoglobin Concentration (MCHC, β=-0.90) and increasing Hematocrit (β=3.40) after the adjustment of ferritin level, serum creatinine (β=5.8 p<0.01), microglobulin, uric acid, and age. Anaemia cases from genetic reasons have been ruled out by this study.Conclusion:Similar cadmium level has been found as compared to other studies in the US and Europe. Women appeared to have adverse erythrocyte effects though with slightly lower cadmium level as compared to men. This might partly result from the decreasing renal function to produce efficient erythroprotein. Further animal experiments were suggested for the confirmation.
    日期: 2006-11
    關聯: Epidemiology. 2006 Nov;17(6):S495.
    Link to: http://journals.lww.com/epidem/Fulltext/2006/11001/Body_Burden_of_Cadmium_and_its_Relations_to.1330.aspx
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1044-3983&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241443402351
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