國家衛生研究院 NHRI:Item 3990099045/4619
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    題名: Prenatal and Postnatal Exposure to Phthalates in Central Taiwan
    作者: Lin, S;Ku, HY;Chen, JW;Su, BH;Chen, HY;Angerer, J;Wang, SL
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Background: Exposure to phthalates may bring adverse health effects, including reproductive and developmental abnormalities, among others. Methods: We studied phthalate ester metabolites in pregnant women and their newborns in a perspective cohort from the general population. Eleven phthalate metabolites (MEHP, 5OH-MEHP, 2cx-MEHP, 5cx-MEPP, 5oxo-MEHP, MiBP, MnBP, MBzP, OH-MiNP, cx-MiNP and oxo-MiNP) representing the exposure to five commonly used phthalates (DEHP, DiBP, DnBP, BP, DiNP) were measured by fully automated LC-LC/MS-MS-system in urine, cord serum, and human milk in 100 pregnant women and their children aged 2–3 years and 5– 6 years from Central Taiwan during 2001–2006. Metabolic rates of each metabolite from toxicokinetic studies were taken into account to estimate the original levels of parent compounds. Correlations among metabolites of the same parent compound were tested. Prenatal and postnatal exposures to phthalates in the young children were assessed. Results: Urinary total phthalate metabolite concentration was found to be higher in 2-year-old children (geometric mean 5 398.6 m g/L, 95% C.I.: 282.6 –562.3) and 5-year-old children (333.7, 251.8 – 442.2) than the pregnant women (205.2, 172.7–243.8). The concentration of urinary phthalate metabolite was higher for DEHP metabolites (2yr old children: 200.3; 5yr old children: 152.3; pregnant women: 102.2), followed by MnBP (2yr: 100.4; 5yr: 75.1; p.w.: 72.3), MiBP (2yr: 17.2; 5yr: 25.2; p.w.: 12.5), and MBzP (2yr: 3.40; 5yr: 3.61; p.w.: 0.96). The proportion of DiNP (a phthalate widely used in toys and now used to replace DEHP) metabolites was higher in children urine samples than in adult samples (2y: 17.5; 5y: 27.7; p.w.: 1.71). Our urinary DEHP metabolite percentages were similar to the profiles reported in literature, except for a slightly lower 5OH-MEHP proportion. DiNP metabolite percentages varied among the three groups, and differed from those reported in literature. DBzP-derived metabolites are MBzP and MnBP. We observed no correlation between the concentrations of these two metabolites. We suspect that DnBP is probably contributing to the formation of MnBP. The concentrations of phthalate metabolites are much lower in cord blood samples (GM 5 37.5, 95% C.I.: 33.8 – 41.5) and milk (14.9, 11.0 –20.2) compared to urinary samples. The compositions of the phthalate metabolites found in these matrices are also very different. DEHP metabolite levels in pregnant women urine samples and their corresponding cord blood samples are significantly correlated (Pearson correlations coefficients for 5cx-MEPP: 0.53, P , 0.01; 2cx-MEHP: 0.44, P , 0.05; 5OH-MEHP: 0.39, P , 0.05; sum of DEHP-derived metabolites: 0.39, P , 0.05). Conclusions: Children presented higher metabolite levels than adults. Metabolites in urine are mainly from DEHP, followed by DEHP, DnBP/BBP, and then DiNP. The levels of DiNP metabolites found in children were much higher than in pregnant women. Although phthalate metabolite levels in milk and cord blood are low, cord blood metabolite levels are well correlated with maternal urinary metabolite level. DEHP metabolites may cross the placental barrier. Maternal urinary metabolite levels during pregnancy may be useful for prenatal exposure measurement to the offspring.
    日期: 2008-11
    關聯: Epidemiology. 2008 Nov;19(6):S106.
    Link to: http://dx.doi.org/10.1097/01.ede.0000339851.86819.c1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1044-3983&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000260191900315
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