國家衛生研究院 NHRI:Item 3990099045/4612

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Title:	The metabolic syndrome in university students with family history of diabetes mellitus - a preliminary report of the University Smoking and Obesity Assessment Program (University SOAP)
Authors:	Lu, CL;Fuh, MMT;Chang, HY;Chu, NF;Yeh, MK;Chang, CT;Chen, RH;Hsieh, LW;Liu, CS;Lee, CC;Lin, CC
Contributors:	Division of Health Policy Research and Development
Abstract:	Background and Aims:In order to evaluate the impact of the family history of diabetes on the healthy and young university students in Taiwan, students were randomly recruited from 2 universities under the University SOAP. Materials and Methods:From Sept. 2003 to Apr. 2004, 656 students were enrolled. All the participants were measured BMI, blood pressure, waist and hip circumferences and other biochemical variables including fasting serum glucose, TG, cholesterol, HDL-Chol, LDL-Chol, uric acid, renal and liver functions. Meanwhile, family history of diabetes, hypertension, dyslipidemia,obesity, coronary artery disease (CAD), and cerebral vascular accident (CVA) were collected. Personal habitudes of smoking and physical activity were also recorded. The descriptive statistics and logistic regression were used for data analysis.Results:According to the database of the University SOAP, 209 cases had diabetes in their family and only 274 cases without any family history. The incidence of different co-morbidities occurring in students with family history was significantly increased in BMI (p = 0.000), diastolic blood pressure(p = 0.024), systolic and/or diastolic blood pressures (p = 0.029) and anyone of the co-morbidities as a group (p = 0.012) as compared with students without family history. By using the gender approach, the results were interestingly disclosed that the male students had significantly higher odds of having co-morbidities of BMI (p = 0.000), diastolic blood pressure (p =0.015), systolic and / or diastolic blood pressures (p = 0.011), HDL-Chol (p= 0.043) and any one of the co-morbidities as a group (p = 0.004) in diabetes family, whereas, no statistical difference in term of incidence of comorbidities was found in female students with or without family history.Furthermore, metabolic syndrome in this student cohort, the result was demonstrated that metabolic syndrome (p = 0.007) was significantly higher in odds ratio in students with family history.Again, by gender analysis, onlymale student had significantly higher odds of having metabolic syndrome(p = 0.011) in family history group.Conclusion: These results clearly indicated that the family history of diabetes has already had anthropometric and metabolic impacts on the young,active and otherwise healthy offspring of next generation at the university ages in all aspects of the co-morbidities of diabetes and metabolic syndrome.The university female gender, however, seemed to be spared at that age. The intervention program for early primary prevention of this insidious developing insulin resistance syndrome would be remaining a great challenge.
Date:	2005
Relation:	Diabetologia. 2005;48(Suppl. 1):A146.
Link to:	http://www.springerlink.com/content/k78702m5213752v1/
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0012-186X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000231743200390
Appears in Collections:	[Hsing-Yi Chang] Conference Papers/Meeting Abstract

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