國家衛生研究院 NHRI:Item 3990099045/4592
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    题名: Gender difference in interaction between ADRA2A gene and ADRB3 gene on bone density among schizophrenic patients with exposure to antipsychotics
    作者: Lan, TH;Chiu, HJ;Hu, TM;Lin, KM;Loh, EW;Lee, MY;Sun, HR
    贡献者: Division of Mental Health and Addiction Medicine
    摘要: Objective: A lower bone density is suspected prevalent among Schizophrenia patients while compared to the general population. This study is to explore the gene-gene interaction pn bone density in male schizophrenic patients from ADRA2A gene and ADRB3 gene. Method: This is a multi-center, investigator-initiated, naturalistic study project. Here we enrolled 119 male in patients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder from two psychiatric hospitals in Taiwan. Bone density indicated in BUA was measured for all subjects by using QUS-2 over calcaneal bone. Descriptive data of age, sex, height, body weight,medical or surgical past history, activity level, smoking and the antipsychotics used in the past two years were collected. Four candidate genes including ADRA1A,ADRA2A,ADRB3,HTR2A have been genotyped by PCR or DHPLC. Results: After controlling for gender, age, previous antipsy-Chotics treatment, and BMI, the absolute regression coefficient of BUA of an interaction term between ADRA2A gene and ADRB3 gene for an individual male is −21.0 ± 10.0(p-value=0.03).Conclusion: It is suggested that the interaction betweenADRA2A gene and ADRB3 gene indeed modified the bone density effect in our male schizophrenic patients significantly.
    日期: 2006-09
    關聯: European Neuropsychopharmacology. 2006 Sep;16(Suppl.4):S427.
    Link to: http://dx.doi.org/10.1016/S0924-977X(06)70544-2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-977X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000240771301210
    显示于类别:[林克明(2004-2009)] 會議論文/會議摘要
    [羅爾維(2004-2012)] 會議論文/會議摘要

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