國家衛生研究院 NHRI:Item 3990099045/4524

NHRI > Institute of Cellular and Systems Medicine > Chun-Chin Tony Liang(2004-2009) > Periodical Articles > Item 3990099045/4524

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4524

Title:	Local and systemic expression of insulin-like growth factor-I (IGF-I) mRNAs in rat after bone marrow ablation
Authors:	Tanaka, H;Wakisaka, A;Ogasa, H;Kawai, S;Liang, CT
Contributors:	Division of Gerontology Research
Abstract:	Local and systemic expression of insulin-like growth factor-I (IGF-I) during bone formation was studied using the rat bone marrow ablation model. The temporal expression pattern of IGF-I mRNA in rat femurs was examined. The IGF-I mRNA level was enhanced rapidly after ablation reaching a level threefold greater than basal by day 3 (P < 0.01) and declined to basal or below basal level by day 5. Histological analysis showed that IGF-I immunoreactivity was predominantly associated with the mesenchymal cells at the bone/connective tissue interface and osteoblastic cells at active sites of bone formation. Serum level of IGF-I increased 50 and 130%, respectively (P < 0.005), over the basal level at days 3 and 6. We also investigated the systemic expression of IGF-I in liver and kidney. In contrast, hepatic IGF-I gene expression decreased 37 and 48%, respectively, at days 3 and 6 after marrow ablation (P < 0.001). Kidney IGF-I mRNA levels also fell 13 and 27%, respectively, at days 3 and 6 (P < 0.005). The present findings suggest that locally produced IGF-I during bone formation may not only serve as an autocrine/paracrine factor but also influence systemic expression of IGF-I in other organs.
Date:	2001-10
Relation:	Biochemical and Biophysical Research Communications. 2001 Oct;287(5):1157-1162.
Link to:	http://dx.doi.org/10.1006/bbrc.2001.5711
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000171552200020
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035850779
Appears in Collections:	[Chun-Chin Tony Liang(2004-2009)] Periodical Articles

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