國家衛生研究院 NHRI:Item 3990099045/4515
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4515


    Title: Assessment of similarity between dissolution profiles
    Authors: Ma, M;Wang, B;Liu, J;Tsong, Y
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: In vitro dissolution equivalence has been assessed through profile comparison between the test and reference formulations for postapproval changes. Functions of the absolute mean difference and average squared mean differences were two of the often-used criteria to evaluate distance or similarity between general profiles. The two functions and their methods of moment estimators are studied in this paper as an application to similarity assessment of two dissolution profile. Due to the complexity of the distributions of these estimators, the confidence intervals obtained from the bootstrap method were used for testing the hypothesis of dissolution similarity. The size and power of two procedures are examined with a simulation study. A numerical example is used to illustrate the application of the procedures.
    Date: 2000
    Relation: Journal of Biopharmaceutical Statistics. 2000;10(2):229-249.
    Link to: http://dx.doi.org/10.1081/bip-100101024
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1054-3406&DestApp=IC2JCR
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033823162
    Appears in Collections:[Jen-Pei Liu(1998-2002)] Periodical Articles

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