國家衛生研究院 NHRI:Item 3990099045/4472
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4472


    Title: Serum leptin levels in preterm, healthy and sick-term newborns
    Other Titles: 早産兒、足月健康兒及足月病兒血中瘦體蛋白之分析
    Authors: Su, P;Wang, S;Chen, J;Chang Lai, C;Jian, S
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: Leptin, a hormone that signals the brain about the status of body (fat) energy stores, has recently been shown to play a role in the regulation of several hypothalamic pituitary axes, including the growth hormone axis. To investigate a potential association of serum leptin concentrations and clinical condition in preterm, sick term and healthy term newborns, serum leptin concentrations were evaluated in 104 newborns. Twenty-eight of them were healthy term (18 males and 10 females; gestational age, 37-42 weeks), 21 were sick term (12 males and 9females; gestational age, 37-42 weeks) and 55 were preterm neonates (35 males and 20 females; gestational age: 26-37 weeks). Leptin values correlate positively with birth weight, birth length, head circumference, waist circumference, hip circumference, body surface, weight/length ratio, and gestational age (r= 0.38, 0.42, 0.29, 0.21, 0.29, 0.40, 0.31 and 0.28), respectively. The concentrations of leptin are statistically significantly higher (p<0.05) in term neonates (3.02?2.94 ng/ml) than preterm neonates (1.93?2.21 ng/ml). Female infants also have significantly higher (p<0.05) serum leptin values than male infants in preterm and healthy term groups. We also found leptin present in venous blood after 26 weeks of gestation.
    Date: 2002-09
    Relation: Acta Paediatrica Taiwanica. 2002 Sep;43(5):249-254.
    Link to: http://www.airitilibrary.com/searchdetail.aspx?DocIDs=16088115-200210-43-5-249-254-a
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036763581
    Appears in Collections:[Shu-Li Wang] Periodical Articles

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