國家衛生研究院 NHRI:Item 3990099045/4449
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    题名: Increased mortality risks of pre-diabetes (impaired fasting glucose) in Taiwan
    作者: Wen, CP;Cheng, TYD;Tsai, SP;Hsu, HL;Wang, SL
    贡献者: Division of Health Policy Research and Development;Division of Environmental Health and Occupational Medicine
    摘要: OBJECTIVE - The objective of this article was to assess mortality risks at different levels of fasting blood glucose (FBG) in Taiwan, with particular attention to those pre-diabetic subjects with impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS - Governmental employees and schoolteachers were followed up for an average of 11 years. With the use of Cox regression analyses, mortality risks were calculated for 36,386 subjects, aged 40 - 69. RESULTS - FBG >= 110 mg/dl was associated with increased mortality risks for all causes, cardiovascular diseases (CVD), and diabetes. IFG, when defined as 110-125 mg/dl, was associated with a significant increase for CVD and/or diabetes mortality. These mortality risks remained elevated when known CVD risk factors were adjusted for. The IFG group shared risk factor characteristics more with the FBG >= 126 mg/dl group than with the FBG < 110 mg/dI group. When IFG was defined as 100-125 mg/dl, the number of subjects quadrupled, but mortality risks diminished substantially because of the inclusion of 100-109 mg/dl group. The lowest FBG group, 50-75 mg/dl, had a significant 2-fold risk from all causes. CONCLUSIONS - There was an overall J-shaped relationship between all-cause mortality and FBG. IFG, when defined as 110-125 mg/dl, is an independent risk factor and should be aggressively treated as a disease because its Subsequent mortality risks for CVD and diabetes were significantly increased. The newly defined IFG at 100-125 mg/dl did not have the predictive power for later increases in CVD or diabetes mortality.
    日期: 2005-11
    關聯: Diabetes Care. 2005 Nov;28(11):2756-2761.
    Link to: http://dx.doi.org/10.2337/diacare.28.11.2756
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0149-5992&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000234548300026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=29544445210
    显示于类别:[溫啟邦(2001-2010)] 期刊論文
    [王淑麗] 期刊論文

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