國家衛生研究院 NHRI:Item 3990099045/4417

NHRI > National Institute of Environmental Health Sciences > Kuen-Yuh Wu(2001-2008) > Periodical Articles > Item 3990099045/4417

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4417

Title:	Oxidative DNA damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): Influence of 4,4 '-methylenebis (2-chloroaniline) exposure and smoking
Authors:	Chen, HI;Liou, SH;Ho, SF;Wu, KY;Sun, CW;Chen, MF;Cheng, LC;Shih, TS;Loh, CH
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between oxidative DNA damage and MBOCA exposure. In addition, we examined the effects of different confounders on the plasma level of 8-OHdG. We undertook a cross-sectional survey at four MBOCA-producing factories in Taiwan (158 subjects). Plasma 8-OHdG levels and urinary MBOCA concentrations were measured by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). Personal characteristics were collected by questionnaire. The workers were classified according to their job titles as exposed (n=57) or unexposed (n=101) groups as well as classified according to urinary MBOCA levels as high urinary MBOCA (>20 mu g/g creatinine) (n=45) or low urinary MBOCA (n=108) groups. Neither the MBOCA-exposed workers nor the high urinary MBOCA workers had a significant increase in the mean plasma 8-OHdG level, even after adjustment for potential confounders. Age and gender were significantly positively correlated with plasma 8-OHdG levels. Smokers among high urinary MBOCA workers also had significantly higher 8-OHdG levels than non-smokers among high urinary MBOCA workers. Our study provides evidence that smoking rather than MBOCA exposure induces elevation of plasma 8-OHdG levels among workers exposed to MBOCA, indicating that oxidative DNA damage does not play an important role in the carcinogenic processes of MBOCA.
Date:	2007-09
Relation:	Journal of Occupational Health. 2007 Sep;49(5):389-398.
Link to:	http://dx.doi.org/10.1539/joh.49.389
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1341-9145&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000250014700007
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=37549005157
Appears in Collections:	[Kuen-Yuh Wu(2001-2008)] Periodical Articles [Saou-Hsing Liou] Periodical Articles

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