國家衛生研究院 NHRI:Item 3990099045/4412

NHRI > National Institute of Cancer Research > Jacqueline Whang-Peng(1996-2007) > Periodical Articles > Item 3990099045/4412

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4412

Title:	Effect of age on pulmonary metastases and immunotherapy in young and middle-aged mice
Authors:	Chen, YM;Wang, PS;Liu, JM;Hsieh, YL;Tsai, CM;Perng, RP;Whang-Peng, J
Contributors:	National Institute of Cancer Research
Abstract:	Background: We used B16-F1O (B16) melanoma tumor cells and syngeneic C57BL/6 (B6) mice as a study model for pulmonary metastases, to better understand whether or not there exist differences in tumorigenicity and in the effectiveness of immunotherapy as a function of host age (1-, 3-, 12- and 24-month-old). Methods: Intravenous injection of B16 melanoma cells were administered to B6 mice of different ages with/without interleukin (IL)-2 and IL-12 daily treatment. Tumor growth, splenocyte function, serum cytokines (IL-10, interferon-γ, vascular endothelial growth factor) and survival were compared. Results: The study showed that, without IL-2 and IL-12 treatment, middle-aged mice suffering from pulmonary metastases had fewer pulmonary metastases and better survival than younger mice suffering from pulmonary metastases. Three days' IL-2 plus IL-12 treatment could not prolong mice survival, but prolonged treatment significantly improved the survival of both the younger and older tumor-bearing mice, especially the older mice, despite the fact that the younger mice had a better serum cytokine and splenocyte cellular immune response to cytokine treatment. Conclusion: The young B6 mice that suffered from B16 pulmonary metastases had a poorer prognosis than the middle-aged mice. Short-term IL-2 plus IL-12 treatment is ineffective in prolonging survival, and a longer duration of treatment is needed. This kind of immunotherapy was effective in both the young and middle-aged mice, but it was more effective in the middle-aged mice.
Date:	2007-03
Relation:	Journal of the Chinese Medical Association. 2007 Mar;70(3):94-102.
Link to:	http://dx.doi.org/10.1016/S1726-4901(09)70338-7
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1726-4901&DestApp=IC2JCR
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34247382458
Appears in Collections:	[Jacqueline Whang-Peng(1996-2007)] Periodical Articles [Ming Jacqueline Liu(1996-2007)] Periodical Articles

Files in This Item:

File	Description	Size	Format
SCP34247382458.pdf		134Kb	Adobe PDF	774	View/Open

Loading...