Two new cyclic peptides, cyclosquamosin H (1) and 1 (2), together with six known cyclic peptides, squamin A (3), squamin B (4), cyclosquamosin A (6), cyclosquamosin D (7), cyclosquamosin E (8), and cherimolacyclopeptide B (9), were isolated from the seeds of Annona squamosa. All structures were confirmed by 2D nuclear magnetic resonance, chemical evidence, and electrospray ionization-mass spectromotry/mass spectrometry (ESI-MS/MS). Compound 9 was isolated from this plant for the first time. In the anti-inflammatory assay, compound 7 showed an inhibitory effect on the production of pro-inflammatory cytokines within lipopolysaccharide and Pam3Cys-stimulated J774A.1 macrophages.
Date:
2008-01
Relation:
Journal of Agricultural and Food Chemistry. 2008 Jan;56(2):386-392.
