國家衛生研究院 NHRI:Item 3990099045/4335
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4335


    Title: Bilateral-array focused ultrasound transducer with dual-frequency mode for blood-brain barrier opening in presence of microbubbles
    Other Titles: World Congress on Medical Physics and Biomedical Engineering - Surgery, Minimal Invasive Interventions, Endoscopy and Image Guided Therapy
    Authors: Wu, SK;Lee, PC;Lee, YS;Wu, XY;Fu, WM;Lin, WL
    Contributors: Division of Medical Engineering Research
    Abstract: In this study, we investigated the local blood-brain barrier (BBB) opening produced by a bilateral two-element spherical ultrasound transducer with dual-frequency mode in presence of micro-bubbles (MB). Both diameter and radius of curvature for the ultrasound transducer are 10.0cm, and the driving frequency is 10kHz difference for the left and the right elements to generate an oscillatory-amplitude focal zone. The ultrasound sonication parameters are pulse length 10ms, duty cycle 1%, sonication duration 20s or 60s, and peak negative pressure 0.53 MPa, with different doses of MB. The ultrasound contrast agent (UCA), SonoVue, was used as the MB to enhance the BBB opening and Evans blue (EB) to evaluate the opening. The in vivo experimental results showed that this focused ultrasound transducer with dual-frequency mode can enlarge the BBB opening region as compared with the single-frequency mode. The results of this study indicated that dual-frequency focused ultrasound producing an oscillatory-amplitude focal zone is promising for opening a larger local BBB with less blood vessel damage.
    Date: 2009-07-09
    Relation: World Congress on Medical Physics and Biomedical Engineering.2009 Sep;25(6):16-19.
    Link to: http://dx.doi.org/10.1007/978-3-642-03906-5_6
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000280419800006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77949393763
    Appears in Collections:[Others] Conference Papers/Meeting Abstract

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