國家衛生研究院 NHRI:Item 3990099045/4306
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4306


    Title: Methamphetamine-induced expression of zif268 mRNA is prevented by haloperidol in mice lacking mu-opioid receptor
    Other Titles: Methamphetamine-induced expression of zif268 mRNA is prevented by haloperidol in mice lacking μ-opioid receptor
    Authors: Tien, LT;Ho, IK;Ma, T
    Contributors: Division of Mental Health and Addiction Medicine
    Abstract: We investigated the role of μ-opioid receptor (μ-OR) and dopamine receptor in the modulation of methamphetamine (METH)-induced expression of zif268 mRNA in the striatum of mice. Four groups of wild-type and μ-OR knockout mice were given a single daily intraperitoneal injection of saline (control; group 1) or METH (10 mg/kg; groups 2-4) for 7 consecutive days. On day 11 (after 4 abstinent days), groups 1 and 2 were challenged with saline, group 3 was challenged with METH (10 mg/kg), and group 4 was challenged with dopamine receptor antagonist haloperidol (0.06 mg/kg, subcutaneous injection) plus METH (10 mg/kg). Two hours after the last saline or METH injection, mouse brain tissues were taken for zif268 mRNA analysis using in situ hybridization histochemistry. In comparison to corresponding saline control group (group 1), striatal zif268 mRNA levels were unchanged in group 2 and increased in group 3 in both wild-type and μ-OR knockout mice and without genotype difference. METH challenge-enhanced expression of zif268 mRNA was completely abolished by pre-administration of haloperidol (group 4) in μ-OR knockout mice but not in wild-type mice. The results suggest a crosstalk of the two neurotransmitter systems in modulation of METH-induced IEG expression, because only in μ-OR knockout mice in which dopamine receptors were blocked were METH-induced zif268 expression abolished. METH-induced zif268 expression was not altered in μ-OR knockout mice without blockade of dopamine receptors or wild-type mice with blockade of dopamine receptors.
    Date: 2010-06
    Relation: NeuroToxicolog. 2010 Jun;31(3):326-330.
    Link to: http://dx.doi.org/10.1016/j.neuro.2010.02.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0161-813X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000277966600010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952668950
    Appears in Collections:[Ing-Kang Ho(2006-2011)] Periodical Articles

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