國家衛生研究院 NHRI:Item 3990099045/4301
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4301


    Title: Anti-alpha-enolase autoantibodies are down-regulated in advanced cancer patients
    Other Titles: Anti-α-enolase autoantibodies are down-regulated in advanced cancer patients
    Authors: Shih, NY;Lai, HL;Chang, GC;Lin, HC;Wu, YC;Liu, JM;Liu, KJ;Tseng, SW
    Contributors: National Institute of Cancer Research;Division of Biostatistics and Bioinformatics
    Abstract: OBJECTIVE: Elevation of serum autoantibodies to alpha-enolase (ENO1) is often seen in inflammation diseases. However, it is unclear whether the levels of serum ENO1 autoantibodies could be affected during tumor progression. Hence, we attempted to determine the relative serum ENO1 autoantibody levels in healthy individuals and various stages of patients with lung and breast cancers. METHODS: Sera were obtained from 99 normal individuals, 21 patients with non-cancer-associated diseases and 178 cancer patients, including Stage I, II and IV non-small cell lung cancer, small cell lung cancer and breast cancer. The ENO1 autoantibody levels were determined by enzyme-linked immunosorbent assay. RESULTS: Compared with the healthy individuals, the levels of ENO1 autoantibodies were significantly decreased in Stage IV non-small cell lung cancer, small cell lung cancer and breast cancer patients. Consistently, this phenomenon was also observed in tumor-grafted mice. Using logistic regression analyses, data show that the titer status of ENO1 autoantibody level is highly associated with the late stage of lung and breast cancers when compared with those of healthy controls. In contrast, there were no statistic differences between healthy controls and early stages of non-small cell lung cancer patients, and total amounts of serum immunoglobulin A, immunoglobulin G and immunoglobulin M levels in Stage IV non-small cell lung cancer patients were not significantly distinct from those of the healthy controls. Thus, the decreased ENO1 autoantibody event in malignant stage of cancer patients is not contributed by reduction in total immunoglobulin. CONCLUSIONS: Marked decrease in the basal level of serum ENO1 autoantibodies is a common malignant event of lung and breast cancers, suggesting that ENO1 autoantibody may serve as a prognostic marker to monitor the disease progression of these cancer patients.
    Date: 2010-07
    Relation: Japanese Journal of Clinical Oncology. 2010 Jul;40( 7):663-669.
    Link to: http://dx.doi.org/10.1093/jjco/hyq028
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0368-2811&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000279467300010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954451868
    Appears in Collections:[Szu-Wen Tseng(1997-2007)] Periodical Articles
    [Ko-Jiunn Liu] Periodical Articles
    [Neng-Yao Shih] Periodical Articles
    [Jacqueline Whang-Peng(1996-2007)] Periodical Articles

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