國家衛生研究院 NHRI:Item 3990099045/4297

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Title:	Disruption of microvessels by focused ultrasound with microbubbles to cause the extravasation of macromolecules and observed by two-photon fluorescence microscopy
Other Titles:	World Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors
Authors:	Lu, KW;Huang, CH;Wang, CC;Lin, WL
Contributors:	Division of Medical Engineering Research
Abstract:	In this study, we investigated the permeability variation of blood vessels produced by focused ultrasound in presence of micro-bubbles (MB). Both diameter and radius of curvature for the ultrasound transducer are 1.6 cm, and the driving frequency of the transducer is 1.0 MHz. The parameters of ultrasound sonication are pulse length 10 ms, duty cycle 1%, sonication duration 60s, and peak negative pressure 0.6 MPa. The ultrasound contrast agent (UCA), SonoVue, was used as the MB to enhance the microvessels permeability. We used rhodamine-labeled dextrans as macromolecular drug carrier, and observed their transport in vivo by two-photon fluorescence microscopy (TPM). The results of this study display that focused ultrasound with MB can disrupt the blood vessel walls for the normal tissue and cause the extravasation of macromolecules and the whole process can be observed from the real-time TPM image.
Date:	2009-07-09
Relation:	IFMBE Proceedings.2009 Sep;25(8):306-309.
Link to:	http://dx.doi.org/10.1007/978-3-642-03887-7_88
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000291667000088
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77949905269
Appears in Collections:	[Others] Conference Papers/Meeting Abstract

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