國家衛生研究院 NHRI:Item 3990099045/4249
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    题名: Exposure assessment of airborne acrylamide for occupationally exposed workers by using an isotope-dilution gas Chromatography Coupled with Mass Spectrometry
    作者: Wu, KY;Huang, YF;Chen, MF;Shih, TS;Uang, SN;Mao, IF;Chen, ML
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: OBJECTIVES: To develop a highly sensitive analytical method for very low acrylamide (AA) exposure and to conduct an occupational exposure assessment by the developed method. METHODS: Seventy-five air samples from four plants were collected and analyzed using an isotope-dilution gas chromatography coupled with mass spectrometry (GC/MS). RESULTS: This isotope-dilution GC-MS method is sufficiently sensitive for assessing very low AA level as 4.37 ng m(-3), which is 10- to 7500-fold lower than the current analytical method. Field study showed that most airborne AA was gaseous rather than particulate. The personal exposure levels in workers ranged from 4.37 x 10(-3) mug m(-3) to 94.90 mug m(-3) with a mean of 12.08 mug m(-3). Fifty percent of personal 8-h time-weighted average (TWA) concentrations in the AA production plant exceeded the threshold limit value of 30 mug m(-3) set by American Conference of Governmental Industrial Hygienists. CONCLUSIONS: The field study indicated that 8-h TWA concentrations in workers varied by two orders of magnitude. The highly sensitive method can be used in future health risk assessment of AA exposure, such as those in fast-food restaurants.
    日期: 2010-07
    關聯: Annals of Occupational Hygiene. 2010 Jul;54(5):575-583.
    Link to: http://dx.doi.org/10.1093/annhyg/meq010
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000280415100009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929453199
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