國家衛生研究院 NHRI:Item 3990099045/4232

NHRI > National Institute of Environmental Health Sciences > Ying-Chin Ko(2003-2009) > Periodical Articles > Item 3990099045/4232

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4232

Title:	A characterization of the antioxidant enzyme activity and reproductive toxicity in male rats following sub-chronic exposure to areca nut extracts
Authors:	Wu, PF;Chiang, TA;Chen, MT;Lee, CP;Chen, PH;Ko, AMS;Yang, KJ;Chang, PY;Ke, DS;Ko, YC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	In the present study, areca nut extracts (ANE) administered to male rats by gavage at a dose of 100 mg/kg/day for a period of 15, 30, or 45 days resulted in signs of reproductive toxicity. ANE administration resulted in a significant decline (30-57% in epididymal sperm count and 27-61% in sperm motility) as well as substantial abnormalities in sperm morphology. Significant variances in activities of antioxidant enzymes were also observed. Malondialdehyde (MDA) levels, which represent the level of lipid peroxidation, increased by 16-188% and levels of sialic acid decreased by 2-46% compared with that in controls. These results indicate that ANE induced spermatogenic damage, as indicated by a decrease in sperm counts and sperm motility as well as the activity of antioxidant enzymes, an increase in sperm abnormalities, and alterations in sialic acid and MDA levels. Such effects reflect that ANE administration resulted in reactive oxygen species (ROS)-induced oxidative stress in the testis, cauda epididymis, and sperm of male rats.
Date:	2010-06-15
Relation:	Journal of Hazardous Materials. 2010 Jun 15;178(1-3):541-546.
Link to:	http://dx.doi.org/10.1016/j.jhazmat.2010.01.118
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3894&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000278056300072
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951498077
Appears in Collections:	[Ying-Chin Ko(2003-2009)] Periodical Articles

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