國家衛生研究院 NHRI:Item 3990099045/4226
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    题名: Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia
    作者: Shiao, YM;Lee, CC;Hsu, YH;Huang, SF;Lin, CY;Li, LH;Fann, CSJ;Tsai, CY;Tsai, SF;Chiu, HC
    贡献者: Division of Molecular and Genomic Medicine
    摘要: Myasthenia gravis (MG) is an antibody and complement mediated autoimmune disease. Serum CXC chemokine ligand 13 (CXCL13) was found to be elevated in MG patients and high CXCL13 level was associated with severe clinical stages, especially in females with thymic lymphoid hyperplasia. Both protein and mRNA of CXCL13 and CXC chemokine receptor 5 (CXCR5) in the thymic tissues were significantly higher in MG patients with lymphoid hyperplasia than those with thymoma. Our data indicated that serum CXCL13 can be used as an index of disease severity and ectopic thymic expression of CXCL13 might be associated with aberrant cell trafficking to the thymus of MG.
    日期: 2010-04-15
    關聯: Journal of Neuroimmunology. 2010 Apr 15;221(1-2):101-106.
    Link to: http://dx.doi.org/10.1016/j.jneuroim.2010.02.013
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0165-5728&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000278653100015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951228240
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