國家衛生研究院 NHRI:Item 3990099045/4225
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4225


    Title: Cigarette smoking and proteinuria in Taiwanese men with type 2 diabetes mellitus
    Authors: Hsu, CC;Hwang, SJ;Tai, TY;Chen, T;Huang, MC;Shin, SJ;Wen, CP;Shih, YT;Yang, HJ;Chang, CT;Chang, CJ;Loh, CH;Fuh, MT;Li, YS;Chang, HY
    Contributors: Division of Health Policy Research and Development
    Abstract: P>Aims Cigarette smoking is a well-known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose-response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods Five hundred and nine males with Type 2 diabetes were selected from a cohort participating in a glucose control study in Taiwan. Pack-years of cigarette smoking were calculated to define tobacco exposure. Proteinuria was identified if albumin-to-creatinine ratio was >= 30 mg/g in at least two of three consecutive urine tests. Logistic regression and trend tests were used to delineate the association between smoking status and proteinuria. Results Compared with non-smokers, those who had smoked 15-30 or more than 30 pack-years were respectively 2.78 (95% CI 1.34-5.76, P < 0.01) and 3.20 (95% CI 1.74-5.86, P < 0.001) times more likely to develop proteinuria. The dose-response effect of tobacco exposure on the development of proteinuria is highly significant in all subjects (P = 0.001) and in subgroups with relatively short duration of diabetes mellitus (P < 0.001), good blood pressure control (P = 0.001) and those of young age (P = 0.007). Conclusions The current study shows a clear dose-response effect of cigarette smoking on development of proteinuria in male Type 2 diabetic patients. These findings reinforce the urgent need to encourage diabetic patients to stop smoking regardless of age, duration of diabetes mellitus or status of blood pressure control.
    Date: 2010-03
    Relation: Diabetic Medicine. 2010 Mar;27(3):295-302.
    Link to: http://dx.doi.org/10.1111/j.1464-5491.2010.02947.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0742-3071&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000275095600007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77949346918
    Appears in Collections:[Hsing-Yi Chang] Periodical Articles
    [Chi-Pang Wen(2001-2010)] Periodical Articles
    [Chih-Cheng Hsu] Periodical Articles

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