國家衛生研究院 NHRI:Item 3990099045/4088
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4088


    Title: Ethnic differences in antidepressant response: A prospective multi-site clinical trial
    Authors: Lesser, IM;Myers, HF;Lin, KM;Mira, CB;Joseph, NT;Olmos, NT;Schettino, J;Poland, RE
    Contributors: Division of Mental Health and Addiction Medicine
    Abstract: Background: Although depression is a highly prevalent condition that occurs in all ethnic groups, the influence of ethnicity on treatment response still remains unclear. Methods: A prospective 8-week, open-label clinical trial comparing the efficacy and side effects of citalopram (CIT) with dose escalation (20-60 mg/day) was performed in African-Americans and Caucasians with nonpsychotic major depression. The intent-to-treat sample consisted of 301 participants (169 African-Americans and 132 Caucasians). Results: Although African-Americans were more socially disadvantaged and had a more severe depression, outcomes between the groups were similar. Remission rates were approximately 50% in both groups and about 2/3 of participants met response criteria. Retention was greater than 75% in both groups, with no differences in dropout rate. There were no differences in the number of completers, number of visits made, final dose of CIT, or in side effect profiles. Conclusions: These results confirm the growing body of evidence, including recent studies using measurement-based care, that patients from minority groups have outcomes that are similar to those of Caucasians. The provision of measurement-based care and encouragement of patient participation can reduce ethnic differences in response to treatment for depression.
    Date: 2010-01
    Relation: Depression and Anxiety. 2010 Jan;27(1):56-62.
    Link to: http://dx.doi.org/10.1002/da.20619
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1091-4269&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000273468300009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=75749098461
    Appears in Collections:[Keh-Ming Lin(2004-2009)] Periodical Articles

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