國家衛生研究院 NHRI:Item 3990099045/3979
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 911044      在线人数 : 951
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3979


    题名: JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration
    作者: Li, JP;Fu, YN;Chen, YR;Tan, TH
    贡献者: Immunology Research Center;Division of Molecular and Genomic Medicine
    摘要: JNK pathway-associated phosphatase (JKAP, also named DUSP22) is expressed in various tissues, indicating that JKAP may have an important biological function. We showed that JKAP localized in the actin filament-enriched region. Expression of JKAP reduced cell migration, whereas a JKAP mutant lacking catalytic activity (JKAP-CS) promoted cell motility. JKAP efficiently removed tyrosine phosphorylation of several proteins. We have identified focal adhesion kinase (FAK) as a substrate of JKAP. Over-expression of JKAP, but not JKAP-CS mutant, decreased FAK phosphorylation at tyrosine 397, 576, and 577 residues in H1299 cells. Consistent with these results, decreasing JKAP expression by RNA interference promoted cell migration and Src-induced FAK phosphorylation. Taken together, this study identified a new role for JKAP in the modulation of FAK phosphorylation and cell motility.
    日期: 2010-02
    關聯: Journal of Biological Chemistry. 2010 Feb;285(8):5472-5478.
    Link to: http://dx.doi.org/10.1074/jbc.M109.060186
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1083-351X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000275327200040
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77949333621
    显示于类别:[譚澤華] 期刊論文
    [陳怡榮] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP77949333621.pdf2306KbAdobe PDF989检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈