國家衛生研究院 NHRI:Item 3990099045/3944
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    題名: Genetic variants of IL-6 and its receptor are not associated with schizophrenia in Taiwan
    作者: Liu, YL;Liu, CM;Fann, CSJ;Yang, WC;Chen, YH;Tseng, LJ;Liu, SK;Hsieh, MH;Hwang, TJ;Chan, HY;Chen, JJ;Chen, WJ;Hwu, HG
    貢獻者: Division of Mental Health and Addiction Medicine
    摘要: The pathophysiological process of schizophrenia is still unclear. The levels of interleukine-6 (IL-6) and its receptor, soluble IL-6R, have been reported to be elevated in the plasma and cerebrospinal fluid of schizophrenic patients. In this study, we tested the association of genetic variants of IL-6 and IL-6R with schizophrenia. Genotyping of three single nucleotide polymorphisms (SNP) for each IL-6 (IL-6-1, IL-6-2, and IL-6-3) and IL-6R (rs4845617 = IL-6R1, rs4553185 = IL-6R2, and rs4379670 = IL-6R3) gene was performed in 100 patients with schizophrenia and 113 normal controls. The polymorphisms of IL-6R2 were genotyped using Tetra-primer ARMS PCR. IL-6R3 polymorphisms were genotyped using restriction fragment length polymorphism (RFLP) with Apo I enzyme as the restriction enzyme. All other polymorphisms were genotyped using the direct sequencing method. We found a di-nucleotide haplotype block and a tri-nucleotide haplotype block in the genes of IL-6 and IL-6R, respectively. All six SNPs and their haplotypes failed to show a significant association with schizophrenia. The IL-6-2 SNP showed a nominally significant association with the positive symptoms of schizophrenia (p = 0.0472). We conclude that the genetic variants of IL-6 and IL-6R are not associated with schizophrenia. In order to verify this result, further study using a larger sample size and exploring the association between the genotype of IL-6-2 and plasma level of IL-6 is recommended.
    日期: 2010-01-14
    關聯: Neuroscience Letters. 2010 Jan 14;468(3):330-333.
    Link to: http://dx.doi.org/10.1016/j.neulet.2009.11.026
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3940&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000273879100036
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=72249102808
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