國家衛生研究院 NHRI:Item 3990099045/3930
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 956260      線上人數 : 829
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3930


    題名: KEAP1 E3 Ligase-Mediated Downregulation of NF-kappaB Signaling by Targeting IKKbeta
    其他題名: KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ
    作者: Lee, DF;Kuo, HP;Liu, M;Chou, CK;Xia, W;Du, Y;Shen, J;Chen, CT;Huo, L;Hsu, MC;Li, CW;Ding, Q;Liao, TL;Lai, CC;Lin, AC;Chang, YH;Tsai, SF;Li, LY;Hung, MC
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: IκB kinase β (IKKβ) is involved in tumor development and progression through activation of the nuclear factor (NF)-κB pathway. However, the molecular mechanism that regulates IKKβ degradation remains largely unknown. Here, we show that a Cullin 3 (CUL3)-based ubiquitin ligase, Kelch-like ECH-associated protein 1 (KEAP1), is responsible for IKKβ ubiquitination. Depletion of KEAP1 led to the accumulation and stabilization of IKKβ and to upregulation of NF-κB-derived tumor angiogenic factors. A systematic analysis of the CUL3, KEAP1, and RBX1 genomic loci revealed a high percentage of genome loss and missense mutations in human cancers that failed to facilitate IKKβ degradation. Our results suggest that the dysregulation of KEAP1-mediated IKKβ ubiquitination may contribute to tumorigenesis.
    日期: 2009-10-09
    關聯: Molecular Cell. 2009 Oct 9;36(1):131-140.
    Link to: http://dx.doi.org/10.1016/j.molcel.2009.07.025
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1097-2765&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000271060500013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349970493
    顯示於類別:[蔡世峯] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP70349970493.pdf1427KbAdobe PDF815檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋