國家衛生研究院 NHRI:Item 3990099045/3868
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3868


    Title: A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation
    Authors: Yu, YL;Chen, IH;Shen, KY;Huang, RY;Wang, WR;Chou, CJ;Chang, TT;Chu, CL
    Contributors: Immunology Research Center;Vaccine Research and Development Center
    Abstract: Dendritic cells (DC) play a central role in the initiation and regulation of immune responses. Increasing evidence has indicated that manipulation of DC can serve as a therapeutic mechanism for immunomodulation. In this study we tested some unique compounds isolated from Antrodia cinnamomea, a medicinal fungus in Taiwan, on mouse bone marrow-derived DC activation. A triterpenoid methyl antcinate K (me-AntK) promoted DC maturation by enhancing the expression of MHC class II, CD86, and reducing the endocytosis. TNF-alpha, MCP-1, and MIP-1beta were secreted by DC after me-AntK treatment, indicating augmentation of innate immunity by me-AntK. Interestingly, the me-AntK-activated DC induced Ag-specific T-cell proliferation and facilitated Th2 differentiation. Examining signaling responses, we found that me-AntK treatment uniquely activated JNK and ERK in DC. Our results demonstrate that me-AntK is the first natural triterpenoid to promote the ability of DC to prime Th2 responses. This suggests that me-AntK can potentially be applied to enhance immune responses and modulate DC function in immunotherapy.
    Date: 2009-09
    Relation: European Journal of Immunology. 2009 Sep;39(9):2482-2491.
    Link to: http://dx.doi.org/10.1002/eji.200839039
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2980&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000269786000021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349232883
    Appears in Collections:[Ching-Liang Chu(2005-2010)] Periodical Articles
    [Others] Periodical Articles

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