國家衛生研究院 NHRI:Item 3990099045/3866
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    题名: Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis
    作者: Hou, SC;Chan, LW;Chou, YC;Su, CY;Chen, X;Shih, YL;Tsai, PC;Shen, CKJ;Yan, YT
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious hemorrhages were detected and the vascular smooth muscle cells (vSMCs) surrounding the vessels were drastically reduced in the Ankrd17-deficient embryos, suggesting that the vascular maturation was not completed. Interestingly, vSMC differentiation marker genes were up-regulated in the mutant embryos. Our data have demonstrated the indispensability of Ankrd17 functioning for vascular maturation during early development. The Ankrd17-deficient mice also provide a new animal model for the analysis of the regulatory pathways of the differentiation of vSMC precursor cells.
    日期: 2009-09-03
    關聯: FEBS Letters. 2009 Sep 3;583(17):2765-2771.
    Link to: http://dx.doi.org/10.1016/j.febslet.2009.07.025
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-5793&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000270149800011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=69249215112
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