A simple and practical procedure for the synthesis of 2-aminothiazoles from α-tosyloxyketones and thioureas is described using PEG-400[poly (ethylene glycol-400)] at ambient conditions. The developed protocol is successfully applied for the preparation of an anti-inflammatory drug, Fanetizole.
Date:
2009-06
Relation:
Journal of the Chinese Chemical Society. 2009 Jun;56(3):455-458.