國家衛生研究院 NHRI:Item 3990099045/3793
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12189/12972 (94%)
造访人次 : 956609      在线人数 : 839
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3793


    题名: Alteration of nitric oxide gas on gene expression of endothelin-1 and endothelial nitric oxide synthase by a time- and dose-dependent manner in human endothelial cells
    作者: Weng, YH;Kuo, CY;Chiu, YW;Kuo, ML;Liao, SL
    贡献者: Center for Health Policy Research and Development
    摘要: Our purpose was to investigate the gene expression of endothelin-1 (ET-1) and endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) under various concentrations and periods of exogenous nitric oxide (NO) gas exposure. Cultured HUVECs were exposed to 0, 20, and 80 ppm NO for 0, 24, and 48 h. With NO exposure for 24 h, ET-1 peptide levels decreased in both the 20 and 80 ppm groups. Thereafter, at 48 h, ET-1 peptide levels persistently decreased in the 20 ppm group, but significantly increased in the 80 ppm group. Furthermore, there was a significant decrease in the expression levels of eNOS protein and mRNA in the 80 ppm 48 h group. The data suggest a time- and dose-dependent effect of NO gas exposure on the gene expression of ET-1 and eNOS in HUVECs. A high concentration and long period of NO exposure induces an inhibition of eNOS and enhancement of ET-1, which could lead to vasoconstriction. These findings may have clinical implications in NO therapy regarding the optimal dose and period.
    日期: 2009-04
    關聯: Chinese Journal of Physiology. 2009 Apr;52(2):59-64.
    Link to: http://www.cps.org.tw/index.php?id=138
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-4920&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000265468800001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349554124
    显示于类别:[邱亞文(2005-2013)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP70349554124.pdf214KbAdobe PDF504检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈