國家衛生研究院 NHRI:Item 3990099045/3766
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3766


    Title: Toxicological analysis points to a lower tolerable daily intake of melamine in food
    Authors: Hsieh, DPH;Chiang, CF;Chiang, PH;Wen, CP
    Contributors: Center for Health Policy Research and Development
    Abstract: Intensified food safety concern over melamine has prompted national authorities to assess its tolerable daily intake (TDI) for protection of general population including young children. TDI is calculated by dividing a no-observed-adverse-effect level (NOAEL) by a safety factor (SF). Based on appropriate choices of values, the US Food and Drug Administration determined two TDI values in the unit of mg per kg body weight per day as first 0.63 and then 0.063, while the World Health Organization, 0.5 and then 0.2, as a result of increasing the SF values in calculation. We used a similar procedure, with judicious selection of pertinent values, to obtain a TDI of 0.0081. Arguments in support of this lower TDI value were provided to alert the international community.
    Date: 2009-10
    Relation: Regulatory Toxicology and Pharmacology. 2009 Oct;55(1):13-16.
    Link to: http://dx.doi.org/10.1016/j.yrtph.2009.05.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0273-2300&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000269778600003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=69249229537
    Appears in Collections:[Chi-Pang Wen(2001-2010)] Periodical Articles
    [Po-Huang Chiang] Periodical Articles

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