國家衛生研究院 NHRI:Item 3990099045/3644
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3644


    Title: Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents
    Authors: Lai, MJ;Kuo, CC;Yeh, TK;Hsieh, HP;Chen, LT;Pan, WY;Hsu, KY;Chang, JY;Liou, JP
    Contributors: National Institute of Cancer Research;Division of Biotechnology and Pharmaceutical Research
    Abstract: A series of 1-benzyl-4,5,6-trimethoxyindoles was designed and prepared as a novel class of potent antimitotic agents acting through the colchicine binding site of tubulin. Compounds 10 and 11 showed excellent antiproliferative activity with mean IC50 values of 26 and 27 n M, respectively, in a diverse set of human cancer lines from different organs, including a MDR+ line. They also displayed substantial antitubulin efficacy with IC50 values of 3.5 and 2.6 μM, respectively, representing an improvement over colchicine (IG50=4.3μM).
    Date: 2009-04-17
    Relation: ChemMedChem. 2009 Apr 17;4(4):588-593.
    Link to: http://dx.doi.org/10.1002/cmdc.200800405
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1860-7179&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000265797800012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=65549144450
    Appears in Collections:[Jang-Yang Chang] Periodical Articles
    [Li-Tzong Chen] Periodical Articles
    [Hsing-Pang Hsieh] Periodical Articles
    [Teng-Kuang Yeh] Periodical Articles
    [Ching-Chuan Kuo] Periodical Articles

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