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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3643


    Title: Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells
    Authors: Yeh, CT;Rao, YK;Yao, CJ;Yeh, CF;Li, CH;Chuang, SE;Luong, JH;Lai, GM;Tzeng, YM
    Contributors: National Institute of Cancer Research
    Abstract: Five lanostane (2, 3, 4, 6 and 8) and three ergostane-type (1, 5 and 7) triterpenes isolated from the fruiting bodies of Antrodia camphorata were evaluated for their in vitro cytotoxic data against various cancer cell types. The three zhankuic acids, 1, 5 and 7 displayed the most potent cytotoxic effect with an IC50 value of 22.3-75.0 μM. The compound 3 was selectively cytotoxic in three colon cancer cell lines (HT-29, HCT-116 and SW-480) and a breast cancer model (MDA-MB-231), whereas 8 only showed its cytotoxicity against MDA-MB-231. None of these isolates was toxic to mammary epithelial (MCF10A) and primary foreskin fibroblast (HS68) cells, two human normal cell lines. The compounds 1, 5 and 7 were also demonstrated to induce apoptosis in HT-29 and SW-480 cells, as confirmed by sub-G1 cell cycle arrest. In HT-29 cells, the expression of apoptosis-associated proteins poly-(ADP-ribose) polymerase cleavage, Bcl-2 and procaspase-3 were suppressed by compounds 1, 5 and 7. A mixture containing 4 μM each of compounds 1, 5 and 7 also showed a synergistic cytotoxic effect in HT-29 cells.
    Date: 2009-11-18
    Relation: Cancer Letters. 2009 Nov 18;285(1):73-79.
    Link to: http://dx.doi.org/10.1016/j.canlet.2009.05.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000271167700010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349269114
    Appears in Collections:[賴基銘(2004-2008)] 期刊論文
    [莊雙恩] 期刊論文

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