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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/3620
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| Title: | Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan |
| Authors: | Chi, CY;Tseng, FC;Liu, DP;Chang, YW;Wu, HC;Huang, YF;Hwang, KP;Hsu, YW;Wang, SM;Liu, CC;Wu, HS;Yang, JY;Yang, CF;Wang, JR;Su, IJ |
| Contributors: | Division of Infectious Diseases |
| Abstract: | Background: In Taiwan, trivalent oral poliovirus vaccine (tOPV) is in the routine immunization schedule, but its association with illnesses had not been examined. Objectives: To investigate clinical presentations and viral characteristics of patients with poliovirus isolates. Study design: Clinical data, vaccination records and viral sequences were retrospectively analyzed for patients from whom polioviruses were isolated during 2000-2005. Results: OPV-like strains were the only pathogen identified in 208 children who were diagnosed with lower respiratory tract infection (24.5%), acute gastroenteritis (16.8%) or upper respiratory tract infection (10.6%). Timing of poliovirus isolation relative to the tOPV vaccination was unusual in 59 patients, including 6 before any dose and 53 more than 10 weeks after the 3rd or later dose of tOPV. Sequence analyses of the VP1, 2C and 3C/D regions for 19 poliovirus isolates revealed that 4 had previously reported neurovirulence reversions, 1 had intertypic recombination, and 6 had both. No patient had neurological complications, but 3 died of myocarditis, including 2 with recombinant strains and 1 who never received OPV. Conclusion: This study describes the isolation of OPV-like strains from patients with a variety of illnesses, raising concerns about their pathogenic potential in an area where tOPV is routinely administered. The detection of genetic variations among OPV-like strains warrants continuing surveillance for these variants in patients with severe illnesses besides neurological complications. |
| Date: | 2009-06 |
| Relation: | Journal of Clinical Virology. 2009 Jun;45(2):129-134. |
| Link to: | http://dx.doi.org/10.1016/j.jcv.2009.03.013 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1386-6532&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000267388700010 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67349159709 |
| Appears in Collections: | [蘇益仁(2002-2015)] 期刊論文
[齊嘉鈺] 期刊論文
[曾凡真] 期刊論文
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Size | Format | |
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| SCP67349159709.pdf | | 305Kb | Adobe PDF | 1076 | View/Open |
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