國家衛生研究院 NHRI:Item 3990099045/3601
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3601


    Title: Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity
    Authors: Kasiappan, R;Shih, HJ;Chu, KL;Chen, WT;Liu, HP;Huang, SF;Choy, CO;Shu, CL;Din, R;Chu, JS;Hsu, HL
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: MCT-1 oncoprotein accelerates p53 degradation by means of the ubiquitin-dependent proteolysis. Our present data show that induction of MCT-1 increases chromosomal translocations and deregulated G(2)-M checkpoint in response to chemotherapeutic genotoxin. Remarkably, increases in chromosome copy number, multinucleation, and cytokinesis failure are also promoted while MCT-1 is induced in p53-deficient cells. In such a circumstance, the Ras-mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-mitogen-activated protein kinase signaling activity and the expression of metastatic molecules are amplified. Given a p53-silencing background, MCT-1 malignantly transforms normal breast epithelial cells that are satisfactory for stimulating cell migration/adhesion and tumorigenesis. Detailed analyses of MCT-1 oncogenicity in H1299 p53-null lung cancer cells have shown that ectopically expressed MCT-1 advances xenograft tumorigenicity and angiogenesis, which cannot be completely suppressed by induction of p53. MCT-1 counteracts mutually with p53 at transcriptional levels. Clinical validations confirm that MCT-1 mRNA levels are differentially enriched in comparison between human lung cancer and nontumorigenic tissues. The levels of p53 mRNA are comparatively reduced in a subset of cancer specimens, which highly present MCT-1 mRNA. Our results indicate that synergistic promotions of chromosomal imbalances and oncogenic potency as a result of MCT-1 expression and p53 loss play important roles in tumor development.
    Date: 2009-04
    Relation: Molecular Cancer Research. 2009 Apr;7(4):536-548.
    Link to: http://dx.doi.org/10.1158/1541-7786.mcr-08-0422
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1541-7786&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000265322400009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=65549131527
    Appears in Collections:[Hsin-Ling Hsu] Periodical Articles
    [Shiu-Feng Kathy Huang] Periodical Articles

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