國家衛生研究院 NHRI:Item 3990099045/3597
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    题名: Pharmacogenomic strategy for individualizing antidepressant therapy
    作者: Lin, KM;Perlis, RH;Wan, YJY
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Despite remarkable progress, pharmacotherapy in general, including that for the treatment of depressive conditions, has often ignored the magnitude and clinical significance of the huge interindividual variations in pharmacokinetics and pharmacodynamics, resulting in poor compliance, suboptimal therapeutic effects, and treatment resistance. Advances in pharmacogenomics and computer modeling technologies hold promise for achieving the goals of "individualized" ("personalized") medicine. However, the challenges for realizing such goals remain substantial. These include the packaging and interpretation of genotyping results, changes in medical practice (innovation diffusion), and infrastructural, financing, ethical, and organizational issues related to the use of new information.
    日期: 2008
    關聯: Dialogues in Clinical Neuroscience. 2008;10(4):401-408.
    Link to: http://www.dialogues-cns.org/brochures/39/htm/39_39.asp
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59149085326
    显示于类别:[林克明(2004-2009)] 期刊論文

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